Development of dynamic blood glucose/body fluid ion monitoring system based on Q

Introduction:  

Quart Crystal Microbalance (QCM) is an ultra sensitive mass sensor. Its principle is to use the piezoelectric characteristics of the quartz crystal resonator to convert the change of the surface quality of the quartz crystal oscillator electrode into the frequency change of the output electrical signal of the quartz crystal oscillator circuit, which can monitor the data online in real time through computers and other auxiliary equipment. Its measurement accuracy can reach the level of nanogram, and even the change of mass can be detected, which is equivalent to the single molecular layer or atomic layer. On that account, our research group has independently developed a miniaturized instrument and its research on biological fluids, including:

      (1) The non-invasive blood glucose sensor based on saliva glucose can obtain the patient's blood glucose change map by detecting the micro glucose content in the saliva of diabetes patients, so as to realize the non-invasive blood glucose monitoring in a real sense. In 2019, it obtained the medical device registration certificate and production certificate approved by the State Food and Drug Administration;

      (2) The detection of detection targets with typical physiological significance in biological fluids, including detection of proteins, nucleic acids, antigens, antibodies, etc., is of great significance in cancer, diabetes, oral diseases, etc;

      (3) Electrolyte: rapid detection of K+, Na+, Ca2+, Mg2+plasma is of great significance in earthquake relief and other major accidents;

      (4) Combined with other technologies, the micro process and action mechanism are discussed; Immediate detection of other trace and trace substances;

      (5) The research and development of relevant test strips can realize rapid and qualitative detection of targets.

Representative papers:

1. Zhenxiao Zhang, Qian Dou, Hongkai Gao, Bing Bai, Yongmei Zhang, Debo Hu, Ali K. Yetisen, Haider Butt, Xiaoxia Yang, Congju Li, and Qing Dai*. 30 s Response Time of K⁺ Ion-Selective Hydrogels Functionalized with 18-Crown-6 Ether Based on QCM Sensor. Advanced Healthcare Materials. 2018, 7(5): 1700873

2. Qian Dou, Debo Hu, Hongkai Gao, Yongmei Zhang, Ali K. Yetisen, Haider Butt, Jing Wang, Guangjun Nie*, Qing Dai*. High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring. RSC Advances. 2017, 7(66), 41384- 41390